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- ISSN: 1573-4064
- E-ISSN: 1875-6638
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Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives
- Source: Medicinal Chemistry, Volume 12, Issue 5, Aug 2016, p. 441 - 447
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- 01 Aug 2016
Abstract
A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μ, 18.4μM respectively).
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