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2000
Volume 11, Issue 6
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

37 acetylenic chalcones were designed, synthesized by the Pd/Cu catalyzed Sonogashira coupling reaction, and evaluated for anti-inflammatory activities. A majority of these compounds showed remarkable inhibitions of the expression of inflammatory cytokines in LPS-stimulated macrophages. Six of them demonstrated the dose-dependent inhibition of inflammatory cytokines, and 4f is the most potent antiinflammatory compound. Our results suggest that these active acetylenic chalcones could be further developed as promising candidates for the treatment of inflammatory diseases.

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/content/journals/mc/10.2174/1573406411666150209122749
2015-09-01
2025-05-22
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  • Article Type:
    Research Article
Keyword(s): Acetylenic chalcones; anti-inflammation; cytokines; sonogashira coupling reaction
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