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2000
Volume 9, Issue 7
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Curcumin bioconjugates, with folic acid, fatty acids and dipeptide, have shown much lower MIC than curcumin against clinically isolated Gram-positive, S.viridians, and Gram-negative bacterial strains, E. coli, P. mirabilis and K. pneumoniae. Polynomial regression analysis was performed to establish a correlation between lipophilicity (logP) and antibacterial activity (pMIC), which showed the efficacy of these molecules against the bacterial strains in the following order: E. coli > S viridans = K. pneumoniae > P. mirabilis. The regression coefficients (R2 = 0.62 to 0.91) derived for each strain were correlated significantly and led to a conclusion that it was the amphiphilic nature that governed the antibacterial activity. Thus, the bioconjugate 2, having folic acid attached at active methylene site of curcumin with free phenolic hydroxyls, showed the best result.

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/content/journals/mc/10.2174/1573406411309070014
2013-11-01
2025-06-03
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/content/journals/mc/10.2174/1573406411309070014
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  • Article Type:
    Research Article
Keyword(s): Curcumin bioconjugates; logP; MBC; MIC; regression coefficient
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