Skip to content
2000
Volume 11, Issue 5
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

A new series of (E)-N,2,3-triarylacrylamide derivatives were designed and synthesized as potent anticancer agents. Cytotoxicity of the 26 target compounds was evaluated in vitro against six cancer cell lines (HCT116, A549, MDA-MB-468, HepG2, SKNMC and SK-OV-3) by Sulforhodamine B colorimetric assay. The most promising compound, 4h, was as potent as the reference drug cisplatin (DDP). Preliminary structure–activity relationship (SAR) data provided guidance for further design and discovery of (E)- N,2,3-triarylacrylamide scaffold anticancer agents.

Loading

Article metrics loading...

/content/journals/mc/10.2174/1573406410666141226132926
2015-08-01
2025-06-12
Loading full text...

Full text loading...

/content/journals/mc/10.2174/1573406410666141226132926
Loading

  • Article Type:
    Research Article
Keyword(s): (E)-N; 2; 3-triarylacrylamide; Cytotoxic activity; SARs; synthesis
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test