Skip to content
2000
Volume 11, Issue 3
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Aberrant regulation of epigenetic pathways causes many diseases including aging, cancer, diabetes, viral pathogenesis, drug addiction etc. and it has been estimated that epigenetic aberrations are at least ten to forty times more frequent in cancers than genetic mutations. Present epigenetic modulators hold great promise for a variety of diseases, and important tools for biological applications but these molecules have many dose limiting toxicities and existing paradigms lack desired efficacy. Synthesis and biological studies of epigenetic modulators have been attractive targets for medicinal and synthetic organic chemists in recent years. This review article provides deep insight into the new and under explored epigenetic modulators. These molecules have the potential to be used as unique template with novel pharmacophores.

Loading

Article metrics loading...

/content/journals/mc/10.2174/1573406410666140925150142
2015-05-01
2025-05-26
Loading full text...

Full text loading...

/content/journals/mc/10.2174/1573406410666140925150142
Loading

  • Article Type:
    Research Article
Keyword(s): Aging; and histone; cancer; diabetes; epigenetics; gene
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test