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- ISSN: 1573-4064
- E-ISSN: 1875-6638
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An Expedient Synthesis and Screening for Antiacetylcholinesterase Activity of Piperidine Embedded Novel Pentacyclic Cage Compounds
- Source: Medicinal Chemistry, Volume 10, Issue 2, Mar 2014, p. 228 - 236
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- 01 Mar 2014
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Abstract
The aim of this study was to synthesize and evaluate diazapentacyclic analogs for their acetylcholinesterase (AChE) inhibitory activity. The pentacyclic analogs were synthesized by one-pot three-component domino reactions in a microwave synthesizer. Most of the compounds exhibited moderate to good AChE inhibitory activity, compound 5i showed potent inhibitory activity with IC50 1.12±0.01 μM and this may provide a new lead for developing potential inhibitors for Alzheimer's disease.
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