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2000
Volume 8, Issue 2
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.

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/content/journals/mc/10.2174/157340612800493629
2012-03-01
2025-05-22
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