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Volume 7, Issue 5
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

The positron emitting isotope 89Zr is an ideal radionuclide for use in positron emission tomography (PET) imaging with monoclonal antibodies (mAbs). This article reviews the cyclotron physics of 89Zr production, and the chemical separation methods for isolating it from yttrium target material. 89Zr coordination with the bifunctional chelate desferrioxamine B is discussed, along with the common procedures for attaching the chelate to mAbs. The review is intended to detail the procedure for creating 89Zr labeled mAbs, going from cyclotron to PET.

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/content/journals/mc/10.2174/157340611796799186
2011-09-01
2025-05-19

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  • Article Type:     Research Article
Keyword(s): 89Zr; bifunctional chelate; cyclotron physics; desferal; desferrioxamine; desferrioxamine B; Immuno-PET; mAbs; monoclonal antibodies; positron emission tomography; yttrium target material; zirconium-89

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