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2000
Volume 4, Issue 4
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.

© Bentham Science Publishers
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/content/journals/mc/10.2174/157340608784872280
2008-07-01
2025-10-18

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  • Article Type:     Research Article
Keyword(s): antimalarials; chloroquine-resistance; Naphthalene-amine; P. falciparum; Schiff-base phenol

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