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2000
Volume 2, Issue 3
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

A quantitative structure-activity relationship study has been conducted on two different series of acyclic hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The results suggest that in a few cases, the hydrophobic property of the molecules is the major governing factor. However, in some cases, the polarizability of the molecules is shown to be dominant. The two enzymes, MMP-9 and MMP-13, are shown to behave in a similar fashion with any group of inhibitors.

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/content/journals/mc/10.2174/157340606776930790
2006-05-01
2025-05-22
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