Skip to content
2000
Volume 2, Issue 3
  • ISSN: 1573-4064
  • E-ISSN: 1875-6638

Abstract

M. tuberculosis, M. bovis and M. avium infections cause the most important mycobacterioses leading to increased mortality in patients with AIDS. Various 5-substituted 2'-deoxyuridines, arabinouridines, arabinocytidines and 2'-arabinofluoro-2'-deoxyuridines were synthesized and evaluated for their in vitro inhibitory activity against M. bovis, M. tuberculosis and M. avium. 5-(C-1 Substituted)-2'-deoxyuridine derivatives emerged as potent inhibitors of M. avium (MIC50 = 1-10 μg/mL range); 5-(1-azidovinyl)-2'-deoxyuridine being the most active (MIC50 = 1-5 μg/mL range). The nature of C-5 substituents appeared to be a determinant of anti-mycobacterial activity.

Loading

Article metrics loading...

/content/journals/mc/10.2174/157340606776930745
2006-05-01
2025-05-21
Loading full text...

Full text loading...

/content/journals/mc/10.2174/157340606776930745
Loading

  • Article Type:
    Research Article
Keyword(s): anti-microbial agent; heterocycle; Tuberculosis
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test