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Indazole, a heterocyclic molecule, has emerged as a useful scaffold in synthetic and medicinal chemistry due to its broad biological activity and ease of synthesis. This article thoroughly analyzes unique synthetic methods used to diversify indazole derivatives, such as metal-catalyzed reactions, ecologically friendly approaches, and novel multicomponent reactions. These advances have increased the efficiency and selectivity of indazole synthesis and its structural variety, paving the path for new biological applications. Furthermore, indazole-based compounds have demonstrated promising biological activities, particularly as anticancer, antibacterial, and anti-inflammatory medicines. This review summarizes the present state of indazole research, focusing on synthetic techniques and biological features that make indazole an attractive target for future drug discovery.
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