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image of Effective Synthesis of Dopamine Dimer

Abstract

Background

Dopamine () is a commonly used vasopressor, primarily employed to treat various types of shock, congestive heart failure, and acute renal failure. Dopamine dimer () is an impurity generated during the production process of dopamine raw materials or the metabolism of dopamine drugs themselves.

Methods

This article presents an effective method for synthesizing dopamine dimer through the condensation of methyl 3,4-dimethoxyphenyl acetate () and 3,4-dimethoxyphenylethyl amine (), followed by reduction and demethylation.

Results

The product was synthesized from easily accessible raw materials, achieving a total yield of 48% over five steps.

Conclusion

This synthesis method is simple and beneficial for pharmaceutical companies to adopt and implement.

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2025-01-23
2025-05-10

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Effective Synthesis of Dopamine Dimer
Bentham Science Publishers ; https://doi.org/10.2174/0115734064262975241208063806
/content/journals/mc/10.2174/0115734064262975241208063806
/content/journals/mc/10.2174/0115734064262975241208063806
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  • Article Type:     Research Article
Keywords: vasopressor ; synthesis ; clinical safety ; Dopamine ; impurity ; dimer

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