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- Volume 9, Issue 5, 2012
Letters in Organic Chemistry - Volume 9, Issue 5, 2012
Volume 9, Issue 5, 2012
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New 2-Phenylquinoline Derivatives: Synthesis and Preliminary Evaluation as Antimicrobial Agents
A number of new 2-phenylquinoline derivatives have been synthesized. All the synthesized compounds were evaluated for their antibacterial activity. Most of them showed a good activity against Escherichia coli and Staphylococcus aureus. The minimum inhibitory concentration (MIC) was determined for tested compounds.
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Synthesis of Enantiomerically Pure Nitronyl Nitroxide Radicals Through Chiral Pool
Authors: Xiang-Yang Qin, Yue Ma, Qiao-Feng Wang, Chao Wang, Xiao-Li Sun and Peng LiuTwo pairs of new optically active nitronyl nitroxides derived from N-Boc-D- or L- prolinol are described. The synthetic route consist of (1) the synthesis of chiral aryl aldehydes by Mitsunobu reaction, (2) the condensation of the 2,3- bis(hydroxylamino)-2,3-dimethylbutane with chiral aldehydes to give 1,3-dihydroxyimidazolidine, and (3) the final oxidation of 1,3-dihydroxyimidazolidine with aqueous NaIO4 at 0 °C. Thes Read More
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Unusual Course of the Reaction of Lawesson’s Reagent with β-Phosphoryl- β’-carbethoxyhydrazones: First Synthesis of 5-Mercapto-3-(methylthiophosphoryl) pyrazoles
Authors: Emna Chebil and Soufiane TouilIt is well known that Lawesson’s reagent (LR) reacts with hydrazone derivatives at 80 °C to yield 3-thioxo- 1,2,3-diazaphospholine derivatives. We show, in the present investigation, that the reaction of LR with β- phosphoryl-β’-carbethoxyhydrazones under the same conditions, took an entirely different course and gave a new type of pyrazole derivatives, the 5-mercapto-3-(methylthiophosphoryl)pyrazoles.
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New Route for the Synthesis of Chiral Hydrazine SADP
By Tao JiaA convenient route for the synthesis of (S)-1-amino-2-(1-methoxy-1-methylethyl)pyrrolidine (SADP) was established. The route involved three key steps viz. the Grignard addition to the N-Boc-proline ester (1), nitrosation to the aminoalcohol hydrochloride (3) and O-methylation to the alcohol group of N-nitrosopyrrolidine (4). (S)-1,1-dimethyl– tetrahydropyrrolo[1,2-c]oxazol-3-one (6) was also obtained via the reaction of (S)-1-B Read More
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Bu4N+X-(OAc)2 Assisted Oxidation and Halogenation of Anilines
Authors: Hengchang Ma, Jinxia Wang, Ning An, Wenfeng Li, Lianhua Bai, Xiaojie Jia and Ziqiang LeiThe collaborating partners of DMP and quaternary ammonium salt (TBAF, TBAC, TBAB, TBAI) emerged as powerful oxidation and halogenation reagents in the synthesis of structurally diversified iminoquinones were extensively investigated. The plausible mechanism concerned that the in-situ formed Bu4N+X-(OAc)2 was the key intermediate, and further halogenation reaction occurred via electrophilic substitution process.
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Nano-TiCl4/SiO2: An Efficient and Reusable Catalyst for the Synthesis of Tetrahydrobenzo[a]xanthenes-11-ones
Authors: Bi Bi Fatemeh Mirjalili, Abdolhamid Bamoniri and Leila ZamaniTetrahydrobenzo[a]xanthen-11-ones have been synthesized using 50% nano-TiCl4/SiO2 as a reusable, inexpensive, and efficient Lewis acid catalyst. Short reaction times, high yields, scale up, and easy work-up are the advantages of this protocol.
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Synthesis of (+)-(4S,5S)-Muricatacin via Pd-Catalyzed Stereospecific Hydroxy Substitution Reaction of γ,δ-epoxy α,β-Unsaturated Ester with B(OH)3
Authors: Gowravaram Sabitha, G. Chandrashekhar, D. Vasudeva Reddy and J. S. YadavThe stereoselective synthesis of (+)-(4S,5S)-muricatacin has been achieved involving the palladium-catalyzed stereospecific hydroxy substitution reaction of γ,δ-epoxy α,β-unsaturated ester with B(OH)3.
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Preparation of 2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid: A Key Intermediate for Saxagliptin
Authors: Jingke Li, Shurong Zhang, Hongrui Zhou, Jun Peng, Yue Feng and Xiangnan HuAn optimized synthetic approach to prepare 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid has been reported in a good yield under mild experimental conditions. It was synthesized from 1-adamantanecarboxylic acid via successful reaction with thionyl chloride and sodium diethyl malonate to give dimethyl (1-adamantylcarbonyl) malonate, which was subjected to hydrolysis and decarboxylation by a mixture of acet Read More
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A Convenient Method for the Preparation of 2,4,5-triaryl Imidazoles Using Barium Chloride Dispersed on Silica Gel Nanoparticles (BaCl2-nano SiO2) as Heterogeneous Reusable Catalyst
Authors: Mohammad R.M. Shafiee, Abbas Fazlinia, Najme Yaghooti and Majid GhashangA simple and eco-friendly procedure for the synthesis of 2,4,5-triaryl imidazoles by using Barium chloride dispersed on silica gel nanoparticles (BaCl2-nano SiO2) as heterogeneous reusable catalyst in high yield under thermal conditions has been described.
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An Efficient Synthetic Method for Phenylalanine Containing Crown Ether Ring
Authors: Xia Tian, Fang Li, Jianrong Han, Xiaoli Zhen and Shouxin LiuAn efficient, convenient synthesis method has been introduced for the preparation of phenylalanine containing crown ether ring by nucleophilic substitution, nitrosation and reduction reaction using benzo-crown ether and dimethyl malonate as material. The structures of the product are characterized by 1HNMR, MS and element analysis.
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Synthesis and Reactions of Some New Benzylphthalazin-1-ylaminophenols, 2H-Chromene and 5H-Chromeno[2,3-d]pyrimidine Derivatives with Promising Antimicrobial Activities
A series of (4-benzylphthalazin-1-ylamino)phenols 4-6 were prepared. Bromination of (4-benzylphthalazin-1- ylamino)phenol (1) with bromine afforded the bromophenol derivative 7, while condensation of the isomeric (4- benzylphthalazin-1-ylamino)phenol (2) or 7-(4-benzylphthalazin-1-ylamino)naphthalene-2-ol (3) with arylidenemalononitriles 8a-c in ethanol/piperidine solution afforded chromene derivatives 9a-c and 10 Read More
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A Rapid and Convenient Synthesis of Naphthyridinoyl Pyrazolidinones under Microwave Irradiation Condition
Authors: Muggu V.S.R.K. Chaitanya and Pramod K. DubeyMicrowave-assisted synthesis of naphthyridinoylpyrazolidinones (7a-7j) has been achieved rapidly via the reaction of naphthyridine hydrazide (4) with different β-keto esters and ethoxymethylenemalonic ester (EMME) (5a-5e). Initially, the reaction of naphthyridine hydrazide (4) with various β-keto esters under microwave irradiation for 5 mins at 130oC results in the formation of condensed products 6a-6j. This condensation wa Read More
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Comparative Study for the Aqeous Synthesis of New Generation of Diindolylmethanes Using L-Proline, K10 and Nano-Fe3O4 under Ultrasound Irradiation
Authors: Mohammad Nikpassand, Leila Zare and Mohammad R. MousaviAn efficient nucleophilic addition reaction of indole derivatives with various synthesized azo-linked aldehydes to afford novel derivatives of diindolylmethane was carried out using a catalytic amount of L-proline, K10 and nano- Fe3O4 in aqeous media.
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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