Letters in Organic Chemistry - Volume 19, Issue 5, 2022

A facile synthetic approach to Dakin oxidation utilizing green conditions was demonstrated. A combination of hydrogen peroxide and aqueous choline hydroxide in cooperation with various hydroxyl aryl aldehydes and ketones was used to provide the corresponding dihydric aromatic compounds. The whole procedure was conducted at ambient temperature in an aerobic environment. The scope of ChOH/H2O2 platfor Read More

Formamidine derivatives have been synthesized in excellent yields at room temperature from primary amine and N,N-dimethylformamide dimethylacetal (DMF-DMA) in the presence of a catalytic amount of Al-MCM-41 synthesized from natural bentonite as silica and aluminum source. The advantages of this method are the use of a cheap, stable, non-toxic, and readily available catalyst, easy work-up, improved yields, a Read More

An unprecedented protocol for the efficient and highly chemoselective alkylation of unprotected anilines with deactivated CF3-indole-3-carbinols promoted by In(OTf)3 has been developed. A series of diversified trifluoromethylated (indolyl)phenylmethanes were produced featuring the C-alkylation in moderate to high chemical yields and with high regioselectivities.

One of the most prominent aromatic organic chemical compound is Coumarin having formula C9H6O2 which is widely known for its benefits in drug industry. Colourless crystalline solid having sweet scent is coumarin’s physical identity. It serves various purposes such as in synthesis of medicines, laser dyes, perfumes and many more. Having enormous usages, it becomes important to synthesize such compound so vari Read More

Bismuth (III) nitrate pentahydrate (BN) was found to be a mild and efficient catalyst for the electrophilic condensation of 5-nitroindazole with a wide range of aldehydes to obtain Bis (5-nitro indazolyl) methanes 3 (a-h) at ambient temperature. This was structurally confirmed through FTIR, NMR, and HR-MS technique. Molecular docking studies of all compounds were carried out using breast cancer-causing human estrogen recept Read More

Finding a sustainable, inexpensive way for Ag-NPs synthesis is considered as one of the most important requirements for industrial application. Oxidized starch was prepared using sodium periodate. Oxidized starch (DAS) was characterized by measuring aldehyde content and using FTIR spectroscopy. DAS was used as a reducing and stabilizing agent for the preparation of Ag nanoparticles (Ag-NPs). Factors that may affec Read More

Tetrazoles, as one of the most important synthetic heterocyclic compounds, have so many applications in organic chemistry, the photographic industry, coordination chemistry, explosives and in particular, medicinal chemistry. Numerous methods have been reported in the literature for the synthesis of tetrazoles, but much of them have some drawbacks, including the use of strong Lewis acids or expensive and toxic metals a Read More

α-Monochlorocyclododecanone was synthesized from cyclododecane and 1,3-Dichloro-5,5- dimethylhydantoin (DCDMH) catalyzed with silica gel in MeOH. The product was obtained by crystallization with a nearly 85% yield. The presented method used cheap raw materials, mild reaction conditions, a simple separation method, and an environment-friendly process. Additionally, the current synthesis provided an ideal appr Read More

Novel pyrazole tagged pyridine derivatives 5a-n are synthesized starting from 3-cyano-4- trifluoromethyl-6- thiophenyl 2(1H) pyridone 1. Compound 1 on hydrolysis followed by decarboxylation resulted in 4-trifluoro-methyl-6- thiophenyl 2(1H)pyridone 2. Compound 2 was treated with POCl3 to get 2- chloro-4-trifluoromethyl-6- thiophenyl pyridine 3; further reaction with hydrazine hydrate resulting in the formation of compound 4. C Read More