Letters in Organic Chemistry - Volume 19, Issue 4, 2022

A facile and efficient method is reported for the one-pot transformation of aryl aldehydes to aryl nitriles using hydroxylamine hydrochloride and phosphorus tribromide in PEGDME 250. The conversion of various aryl aldehydes to the corresponding aryl nitriles occurred smoothly in high yields under the present reaction conditions.

Compound KAD22 (5-methoxy-1-methyl-2-{[4-(2-hydroxyphenyl)piperazin-1-yl]methyl}- 1H-indole) was designed as a potential dopamine D2 receptor agonist with antioxidant activity for possible treatment of Parkinson’s disease. The compound was obtained from 5-methoxy-1-methyl-1H-indole- 2-carbaldehyde and 2-(piperazin-1-yl)phenol. KAD22 showed no affinity to dopamine D2 receptor but it is a potent antioxidant. Ex Read More

A simple, efficient and green protocol has been developed for the synthesis of polysubstituted dihydropyridines via one-pot, four-component reaction of aldehydes, arylamines, dialkyl acetylenedicarboxylate, and malononitrile. The reaction was proceeded at room temperature in the absence of catalyst in aqueous ethyl lactate under visible light irradiation. The main advantages of the present approach are mild reacti Read More

In recent years, photocatalytic technology has shown great potential as a low-cost, environmentally friendly, and sustainable technology. Compared to other light sources in photochemical reaction, LEDs have advantages in terms of efficiency, power, compatibility, and environmentally friendly nature. This review highlights the most recent advances in LED-induced photochemical reactions. The effect of white and blue LEDs in re Read More

Aryl sulfonates were developed by ssing an energy-saving and eco-friendly approach, through ultrasound-assisted coupling reaction of readily sodium sulfinates with N-hydroxyphthalimide, under metal-free and mild conditions within 10 min at room temperature.

For the first time in the present study, the non-bonded interaction of the Coniine (C8H17N) with carbon monoxide (CO) was investigated by density functional theory (DFT/M062X/6-311+G*) in the gas phase and water solvent. The adsorption of the CO over C8H17N affected the electronic properties such as EHOMO, ELUMO, the energy gap between LUMO and HOMO, and global hardness. Furthermore, chemical shift tensor Read More

A new series of furan-2-carboxamide and 5-bromofuran-2-carboxamide derivatives have been prepared in good yields using simple procedures. Our strategy was to synthesize compounds containing functional groups that are known to exhibit significant bioactivity, such as amide (8-15), 2,4- dinitrophenylhydrazone (8a-15a), and thiosemicarbazone (8b-15b). These newly synthesized compounds have been characterized with t Read More

“Phase Transfer Catalyst” as additive was exposed to the Passerini three-component reactions and the influence of its accelerating effect on the reaction rate was studied concerning direct involvement of reactant molecules. For the rapid formation of diverse “α-acyloxycarboxamides” using passerini reaction, multicomponent reactions were employed using miscellaneous 2-(prop-2-ynyloxy) benzaldehyde with various aromati Read More

A clean and efficient one-pot protocol for the synthesis of a series of new 2-hydroxy-3- ((3-aryl)(heteroarylamino)methyl)naphthalene-1,4-dione derivatives has been developed by the three-component reaction of 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes, and heterocyclic amines at 90 oC under solvent- and catalyst-free conditions. The procedure avoids the use of toxic solvents, tedious work-up, catalyst, and purifi Read More