Letters in Organic Chemistry - Volume 19, Issue 2, 2022

The 1-(4-hydroxy-6-methyl-2H-pyran-2-on-3-yl)-3-aryl-2-propenones, chalcone analogs derived from dehydroacetic acid (DHA), play a significant role in synthetic organic chemistry and proved to be an important intermediate for the wealth of multifarious biologically active molecules especially heterocyclic compounds. The review is an attempt to compile the transformations of DHA-chalcones to various classes of products.

A series of novel amide and Schiffs base functionalized novel pyrido[1,2-a] pyrimidin- 4-one derivatives was prepared starting from 6-(thiophen-2-yl)/phenyl-4-(trifluoromethyl) pyridin- 2-amine 1a and 1b. These compounds on reacting with EMME afford compounds 2a and 2b, followed by cyclization to afford compounds 3a and 3b. Treatment of compounds 3a and 3b with hydrazine hydrate gave compounds 4a and 4b, whi Read More

Human serum albumin (HSA) was found to catalyze the asymmetric nitroaldol reaction of biphenyl aldehydes with nitromethane to afford the corresponding optically active 2-nitro alcohols. Careful optimization of the conditions for the reaction of 4-phenylbenzaldehyde with nitromethane in water at a neutral pH improved both the reactivity and the enantioselectivity. Finally, the reaction of 4-phenylbenzaldehyde (56 mg, 0.30 Read More

Imidazole and triazine derivatives act as antimicrobial and antitubercular agents. 2D-QSAR determination estimates the pharmacological activity based on the thermodynamic properties of the structure. The structural arrangements and thermodynamic properties of the imidazole derivatives are necessary for the enhancement of pharmacological activity. So, imidazole-triazine clubbed derivatives were designed based on mole Read More

A simple and novel protocol for the facile synthesis of bicyclic hybrid molecular framework of morpholinopyrimidines having six-membered pyrimidine ring fused with the morpholine unit is established. The method has been successfully employed to synthesize both regioisomers of the morpholinopyrimidine derivatives in good to high yields. The strategy is further extended successfully to synthesize bicyclic pyrimidooxa Read More

As a part of our ongoing interest to identify bioactive microbial secondary metabolites, the Red Sea tunicate derived Penicillium commune DY004 was investigated. A new dipeptide, penicillizine A (1) together with cyclo(L-Pro-L-Phe) (2), meleagrin (3), α-cyclopiazonic acid (4) and N-(4-hydroxyphenethyl)acetamide (5) was isolated from the ethyl acetate extract of the cultures of the fungus. The structural determinations Read More

An efficient synthesis of amidoalkyl naphthols from the multicomponent reaction of 2- naphthol, aromatic aldehydes, and benzamide derivatives using PEG-400 as an environmentally friendly solvent is described. The main advantage of this protocol is that the benzamide derivatives with low reactivity, such as 4-nitro benzamide, can react effectively. Also, the molecular structure, IR, and 13C NMR spectra of the synthesized co Read More

Tuberculosis remains a highly infectious disease across the world. In the identification of new antitubercular agents, coumarin clubbed thiadiazole amides have been synthesized and evaluated for in vitro antitubercular activity. Owing to the growing concern of chemicals and their impact on the environment, greener and faster reaction conditions needed to be incorporated. Therefore, we used TBTU as a coupling reagent for effi Read More

Three polycyclic aromatic hydrocarbons derived from benzo[c]phenanthrene have been synthesized through a one-step procedure involving palladium Suzuki coupling and are characterized by 1H and 13C NMR, MS and HRMS spectroscopies. UV-vis absorption and fluorescence properties of these π-conjugated compounds have been evaluated in solutions and strong emission in the blue region of the visible spectrum was n Read More