Letters in Organic Chemistry - Volume 19, Issue 11, 2022

A newly chiral tertiary amine-squaramide has successfully developed and applied into the asymmetric Michael addition of 4-hydroxycoumarin to β,γ-unsaturated α-ketoesters. The catalyst system performed well with a low catalyst loading of 1 mol% under mild reaction conditions. A series of coumarin derivatives were obtained with good yields and enantioselectivities.

A molecular iodine-catalyzed system for the decarboxylative substitution reactions of β-keto acids with N-benzylic sulfonamides via sp3 C-N bond cleavage has been disclosed. This procedure provides a series of α-functionalized ketones in good to excellent yields. Furthermore, the practicability of this method could be manifested efficiently in a gram-scale synthesis.

The novel coronavirus disease (COVID-19) emerged in December 2019. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is still existent all over the world. Researchers worldwide are continuously conducting in silico studies or virtual screening on various phytochemicals and reporting potential candidates that can be developed against COVID-19 after in vitro and in vivo validation. Antiviral Read More

In recent years, free radicals and oxidative stress are associated with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases. Confirming the role of oxidants in numerous pathological situations, including cancer, developing antioxidants as therapeutic platforms are needed. It has been well established that melatonin and its derived metabolites function as endogenous free-r Read More

The preparation of 6-chloro-5-nitrothieno[3,2-e][1,3]thiazin-4-one incorporating 2-(Nmorpholinyl) moiety is achieved via a conventional route. Interaction of the latter substrate with a set of N'-(aryl) benzothiohydrazides 1a-f, in the presence of triethylamine, led to a thiophene ring-opening process with the consequent generation of the respective thiolate salts 8a-f. Alkylation of the latter, using methyl iodide or allyl chloride, Read More

In the present study, the SrCO3@montmorillonite nanocomposite was synthesized by loading Sr(NO3)2 on natural bentonite using a controlled and facile microwave method. The SrCO3@montmorillonite nanoparticles’ characteristics are identified using advanced techniques, such as infrared spectroscopy (IR), energy-dispersive X-ray analysis (EDX), X-ray diffraction analysis (XRD), scanning electron microscopy (SEM), and por Read More

A combinatorial library of pyrimidine hybrids based on 4H-chromene and 4H-pyran privileged structures has been developed by reacting phenyl isothiocyanate with chromene derivatives 1a-j and pyranopyrazoles 2a-f in refluxing dry pyridine, respectively. Thus, the target pyrimidine hybrids 3a-j and 4a-f were obtained in good yields with a simple reaction strategy.

Ag-TiO2 nanocomposite is reported to be an efficient, active, and benign recyclable catalyst for highly efficient synthesis of 1,8-dioxodecahydroacridine derivatives from dimedone, aromatic aldehydes, and several anilines or ammonium acetate in ethanol as a solvent at room temperature in a short reaction time and suitable yield. This catalyst is effortlessly recycled by simple filtration and can be reused Read More

This paper aimed at investigating the reaction of some acyl hydrazides with different terminal dibromoalkanes. This investigation revealed that acyl hydrazide by reacting with 1,4 and 1,5- dibromoalkanes in the presence of DABCO (1,4-diazabicyclo[2.2.2]octane) and TBAB (tetrabutylammonium bromide) underwent a facile intramolecular N2-double-alkylation to form pyrrolidine and piperidine ring derivatives under solvent-free c Read More

New ruthenium complexes bearing bipyridine ligands with different substituents (propyl, hexyl, isobutyl, and benzyl) were synthesized and characterized by MS, NMR, FTIR, and UV/Visible spectroscopy. Moreover, their cytotoxic, anti-carcinogenic, and anti-biofilm activities were evaluated. The electrochemical properties of the complexes have been investigated by cyclic voltammetry. The HOMO and LUMO energ Read More

Esterification of higher free fatty acids content by using a photo-catalyst has recently been proved as the most efficient method for the pretreatment of non-edible oil to synthesize biodiesel. Methods: In the current study, mechanistic details of photo-catalyzed esterification reaction for four different fatty acids through density functional theory (DFT) calculations are explored and compared with un-catalyzed esterifica Read More

In the current work, the adsorption of cytophosphane (cytophosphane is a chemotherapeutic drug and is used to treat several specific autoimmune diseases and malignant processes) on the (5,5) SWCNT was studied using density functional theory (DFT) calculations in terms of geometry, energy gap, charge transfer, molecular electrostatic potential surface, and density of state analysis. The behavior of the binding properties and Read More

A novel tertiary amine squaramide has been successfully developed and applied to catalyze the asymmetric Michael addition between cyclic diketones and β,γ-unsaturated α-ketoesters. The catalyst system performed well with a low catalyst loading of 1 mol% under mild reaction conditions. A series of synthetically and pharmaceutically useful chiral bicyclic compounds were obtained with both high yields (up to 97 Read More