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- Volume 17, Issue 5, 2020
Letters in Organic Chemistry - Volume 17, Issue 5, 2020
Volume 17, Issue 5, 2020
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A Mini-review of the Tropical Plant Cratoxylum fomosum ssp. pruniflorum: Phytochemical and Pharmacological Aspects
By Ninh T. SonThe tropical plant C. formosum ssp. pruniflorum belongs to family Clusiaceae, which is native to Southeast Asia countries. Phytochemical investigations on this plant showed interesting secondary metabolites, comprising the main classes of xanthones, anthraquinones, flavonoids, phenolics, and triterpenoids. Biological assessments established the wide spectrum of properties, either the extracts or isolated compou Read More
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Two Novel π-Conjugated Fluorophores for Dye-Doped LC On-Off Photoluminescence Switching
Authors: Rosita Diana, Barbara Panunzi and Ugo CarusoAmong various classes of Photoluminescent (PL) compounds, soft-matter based materials in which chromophores are embedded in a Liquid-Crystal (LC) host polymer prove to be very attractive in the production of flexible panels and on-off temperature switches. Actually, the obtainment of low cost, easily synthesizable, and stable organic molecules soluble in the LC matrix is a challenge for both scholars and technologists. Here Read More
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Design, Synthesis and Biological Evaluation of 3-(3,4,5-Trimethoxyphenyl)-5-(2-(5-arylbenzo[b]thiophen-3-yl)oxazol-5-yl)isoxazole Derivatives as Anticancer Agents
Authors: Syndla Premalatha, G. Rambabu, Islavathu Hatti and Dittakavi RamachandranA new series of 3-(3,4,5-trimethoxyphenyl)-5-(2-(5-arylbenzo[b]thiophen-3-yl)oxa zol-5- yl)isoxazole derivatives were designed and synthesized. All these derivatives were evaluated for their anticancer activity against various human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer) and MDA MB-231 (breast cancer)-four human cancer cell lines by using MTT assay. Here, etoposide w Read More
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Design, Synthesis and Anticancer Evaluation of 1,2,4-Oxadiazole Bearing Isoxazole-Pyrazole Derivatives
Authors: Bhukya Ravinaik, Dittakavi Ramachandran and Mandava V. Basaveswara RaoA novel library of 1,2,4-oxadiazole bearing isoxazole-pyrazole derivatives (13a-j) were designed, synthesized and evaluated for their anticancer activity towards MCF-7 (breast cancer), A549 (lung cancer), DU-145 (prostate cancer) and MDA MB-231 (breast cancer) human cancer cell lines by MTT assay. Here etoposide used as standard drug. Among them, five compounds (13b, 13c, 13d, 13h and 13i) were exhibited more pote Read More
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Preparation and Application of CuO@RHA/MCM-41 Nanocomposite for the Synthesis of Fused pyrano[4,3-b]chromenones
Authors: Mohammad Nikpassand, Leila Z. Fekri and Afshin PourahmadAn efficient procedure for the synthesis of fused pyrano[4,3-b]chromene derivatives via three-component condensation reaction of aromatic aldehydes, 2-naphthol and 4-hydroxycoumarin, using CuO@RHA/MCM-41 nanocomposite at room temperature, is described. This nanocomposite consists of CuO nanoparticles and MCM-41 matrix obtained from Rice Husk Ash (RHA). This method provides several advantages, such a Read More
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Fast and Efficient One-Pot Three-Component Synthesis of Some 1,2,3,4-Tetrahydro-6-methyl-N-phenyl-5-pyrimidinecarboxamide Derivatives via Biginelli Condensation Reaction
Authors: Şirin Gülten, Ufuk Gezer and Elmas A. GündoğanTetrahydropyrimidine (THPM) synthesis has an enormous importance in organic chemistry and especially in pharmaceutical applications. Pyrimidines are the most active class of N-containing heterocyclic compounds and have different biological properties. The heterocyclic ring system with a thio group occupy a unique position in medicinal chemistry. This type of compounds play an important role in synthetic drugs and Read More
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Chiral Thiazolidine based Organocatalysts: Synthesis and Application in Asymmetric Aldol Reactions
Several novel chiral organocatalysts derived from thiazolidines containing amide and thioureia functionalities were synthesized in good yields. These organocatalysts were tested in the asymmetric aldol reaction of acetone with p-nitrobenzaldehyde. Reaction parameters such as reaction time, catalyst loading and solvent were optimized. Products with conversions up to 84% and enantiomeric ratios (er) up to 84.5:15.5 (R:S Read More
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Cyclization Effect on pKa of the Side Chain of Aspartic Acid in Dipeptides: A DFT Study
Authors: Mohsen Sargolzaei and Majid N. JorabchiCyclic dipeptides are very important compounds that have a wide range of applications in pharmaceutical chemistry and life sciences. In the current work, the acidity of the side chain of aspartic acid was calculated for various linear and a cyclic dipeptide. pKa values were derived using the thermodynamics cycle and DFT/B3LYP approach. The obtained pKa values show strong acidity for cyclic with respect to linear dipepti Read More
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A New Oleanane Triterpenoid from the Roots of Callerya speciosa
From the ethyl acetate extract of the roots of Callerya speciosa (Champ.) Schot. collected in Vietnam, a new oleanane triterpenoid, 22β-acetoxy-3β,24-dihydroxy-12-oleanen-30-oic acid (1), along with three known compounds, medicarpin (2), maackiain (3), and β-sitosterol (4), were obtained. The structure of the new compound was elucidated by HR-MS, 1D and 2D NMR experiments.
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Synthesis of a New Dioxaspiro[bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]deca-1(10),8-dien-4-one Derivative Using Some Chemical Strategies
There are several protocols for the preparation of bicyclic derivatives; however, some methods use dangerous and require special conditions. The aim of this study was to synthesize a new Dioxaspiro[ bicyclo[3.3.1]nonane-oxabicyclo[6.2.0]-deca-1(10), 8-dien-4-one (compound 8). Compound 8 was prepared using some reactions such as; i) etherification, ii) reduction, iii) amidation, iv) imination and v) 2+2 addition. The chemical Read More
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Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction
Authors: Rui Du, Liangliang Han, Zhongqiang Zhou and Victor BorovkovThe synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one, piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions at room temperature. The best solvent in terms of the yield and reaction time was found to be dichloromethane. Most substit Read More
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Volumes & issues
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Volume 22 (2025)
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Volume 21 (2024)
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Volume 20 (2023)
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Volume 19 (2022)
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Volume 18 (2021)
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Volume 17 (2020)
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Volume 16 (2019)
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Volume 15 (2018)
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Volume 14 (2017)
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Volume 13 (2016)
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Volume 12 (2015)
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Volume 11 (2014)
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Volume 10 (2013)
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Volume 9 (2012)
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Volume 8 (2011)
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Volume 7 (2010)
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Volume 6 (2009)
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Volume 5 (2008)
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Volume 4 (2007)
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Volume 3 (2006)
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Volume 2 (2005)
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Volume 1 (2004)
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