Letters in Organic Chemistry - Volume 16, Issue 3, 2019

The non-photolytic method for generation of arylnitroso oxides based on the reduction of nitrosobenzene by triphenylphosphine was used to study the products of the reaction of transphenylnitroso oxide with trans-stilbene. N,α-Diphenylnitrone and benzaldehyde were found to be the main stable products of the reaction, the first stage of which was [3+2]-cycloaddition to form the metastable 1,2,3-dioxazolidine intermediate Read More

The present study reported the preparation of a novel mutual prodrug containing meso-tetra (m-hydroxy phenyl) chlorin (m-THPC), PEG and folate. The folate receptor (FR) targeting compound is a water-soluble chemical incorporating a hydrophilic PEG spacer unit and a reducible selfimmolative disulfide-based linker system between the FR-targeting ligand and the chlorin. The m- THPC-s-s-PEG-Folate was proved to release the pa Read More

Vilsmeier-Haack reaction is one of the most important chemical reactions used for formylation of electron-rich arens. Even though Vilsmeier-Haack reaction was studied on a wide variety of hydrazones of enolizable ketones, literature lacks the examples of the use of 4-substituted cyclohexanones as a substrate. The cyclization potential of hydrazones of cyclic keto compounds is still interested topic of investigation. Read More

1H-Tetrazole 5-acetic acid (TAA) has been explored as a new organocatalyst for the synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-ones derivatives from 2’-aminoacetophenone under solventfree conditions. The method described herein is covenient and the catalyst could be reused. Mechanistic study of the reaction revealed that the reaction passing through initial activation of the aldehyde by the catalyst and the C-C bond forme Read More

A new series of bis/mono ethyl-1-aryl-1H-tetrazole-5-carboxylate has been synthesized by treating respective tetrazole with ethyl chloroformate in THF and DIPEA as a catalyst. The structure of the novel molecule is characterized by FT-IR, 1H-NMR, 13C-NMR, and mass spectra. After conforming the structure, bis/mono ethyl-1-aryl-1H-tetrazole-5-carboxylate was subjected to hydrolysis under both acidic and basic conditions. The h Read More

Background: Tetrahydroindazole, a member of the fused-pyrazole system, is a least studied class of heterocyclic compounds owing to its scarcity in nature. However, a large number of synthetically prepared tetrahydroindazoles are known to show a variety of biological activities such as interleukin- 2 inducible T-Cell kinase inhibitors, AMPA receptor positive allosteric modulators, antitumor, antituberculosis, anti-inflammat Read More

The chemical mechanisms of protonated diamines-catalyzed decarboxylation of oxaloacetic acid anions in water solutions have been studied by using density functional theory. The calculated results show that the activated Gibbs free energy of the decarboxylation step is the highest in the whole diamine-catalytic processes for OA2-, and protonated ethylenediamine (ENH+) is the best catalyst of the five diamines, which is c Read More

2-Amino-4,5-dihydro-3-furancarbonitriles (ADFCs) have attracted much attention due to their utility as valuable synthetic intermediates for the preparation of a series of acyclic and cyclic organic compounds. On the other hand, indoles substituted with furans are highly interesting compounds displaying a wide range of biological and pharmaceutical activities. However, to the best of our knowledge, indole substitute Read More

The optimized structural parameters and electronic properties including frontier molecular orbital (FMO) analysis, molecular electrostatic potential and NBO charge analysis of (E,Z)-2-(4- amino-5-oxo-3-(thiophene-2-ylmethyl)-4,5-dihydro-1,2,4-triazole-1-yl)-N'-(thiophene-2-ylmethylene) acetohydrazide were investigated by using density functional theory (DFT) at B3LYP/6-311++G(d,p) level. The global reactivity paramete Read More

N-Myristoylation, an irreversible protein modification, occurs by the covalent attachment of myristate with the N-terminal glycine of the eukaryotic and viral proteins, and is associated with a variety of pathogens and disease-related proteins. Identification of myristoylation sites through experimental mechanisms can be costly, labour associated and time-consuming. Due to the association of N-myristoylation with various Read More

A part of a running research project directed to building coordinated polymers based on the rigid aromatic s-triazine, the researchers reported the synthesis, characterization, antimicrobial, antioxidant and anti-inflammatory activities of four new transition metal complexes derived from the nanosized diol monomer (H2L ligand) as early representatives of its nanosized o-naphthol-based polyester. The reaction of the new nan Read More