Letters in Organic Chemistry - Volume 10, Issue 8, 2013

An efficient halogenation reaction has been developed with diaryliodonium salts and cuprous halides. Various diaryliodonium salts 1 could perform the reaction with readily available CuBr or CuCl in CH3CN at 80°C, assembling bromoarenes or chloroarenes in up to 92% yields. This provides us a method for the transformation from iodoarenes to other haloarenes.

The synthesis of Azo-3-cyano-iminocoumarins and corresponding N-substituted derivatives is described according to three steps. These dyes which have not previously been described were obtained in good yields and high selectivity. The proposed structures of the dyes were confirmed and characterized by using IR, 1H NMR, 13C NMR and elemental analysis. Their optical properties, studied in chloroform by UV-vis absorption Read More

A simple and efficient indium(III)-catalyzed sp3-sp C-C bond formation reaction via direct coupling of alcohols with terminal alkynes has been developed under mild conditions without any ligand, base or additive, in which both of aromatic and aliphatic alkynes and various alcohols such as benzylic, allylic and propargylic alcohols can be tolerated. This simple reaction system provides an attractive approach to a large numbe Read More

A facile and efficient one-pot preparation of a new series of 1,4-dihydropyridines has been reported via a threecomponent reaction of nano aluminum nitride, aromatic aldehydes and benzyl-3-oxobutanoate or 2-methoxyethyl-3- oxobutanoateat 80 °C in water. Using this methodology, Hantzsch1,4-dihydropyridine derivatives were synthesized in a simple pathway without the use of a catalyst or an organic solvent.

The first entry to the 7,9,12b-triazabenzo[a]aceanthrylene ring system has been accomplished starting from readily accessible 1-(2-bromoacetyl)-β-carboline via 5-aminocanthin-4-one in four steps. The 8-oxo derivative, which can be considered as an annulated diazaacridone, exhibits significant antimicrobial properties.

A simple and practical procedure for the synthesis of 2-arylbenzimidazoles through a one-pot condensation reaction of o-phenylenediamine and various aromatic aldehydes in the presence of nano-Copper Y Zeolite (NCZ) as a catalyst in ethanol at room temperature has been described. The CuY Zeolite nanocatalyst was characterized with SEM image. Some of the major advantages of this practical procedure are use of availa Read More

Synthesis of chiral acetals of phenol and bromophenol was carried out using (–) menthol as a pure chiral auxiliary. Metalation of these chiral acetals, followed by nucleophilic attack on different aromatic and aliphatic aldehydes produced chiral products through directed ortho metalation (DoM). Chiral menthoxymethyl (OMen) is developed as a new oxygen based chiral directed metalation group (DMG) for benzene and sub Read More

Ten known compounds were isolated from the leaves and barks of Walsura chrysogyne. One of the known compounds which was isolated as crystal was structurally confirmed by X-ray crystallography and named chrysura (5). The stereochemistry of the (20R, 24ξ)-ocotillone (9) which previously established by chemical methods has been elucidated by interpretation using 1D, 2D NMR and comparison with closely related compoun Read More

Aniliniumcalix[4]arene dimers with peptide bridges to increase hydrogen bonding between amino acids and nucleic acid bases have been synthesized. Three different kinds of peptide bridges containing L-Alanine, L-Phenylalanine, and L-Tyrosine were prepared by liquid phase peptide synthesis. The dimers were characterized by NMR, MS and ESIMS spectrometry.

The development of dual-targeting drug delivery system is helpful to overcome the poor physiochemical properties of chemotherapeutic agents. The RGD sequence has a potential dual-targeting property, with which the chemotherapeutic agents can be delivered to bone tissue and tumor. And the Janus dendrimer which consists of two dendrons with different tasks is useful for improving the effect of polymer on pharmacoki Read More

The 1H–pyrazole-3-carboxylic acid 2 and its remarkably stable acid chlorides 3 can easily be converted into the corresponding carbohydrazide, ester or amide derivatives 4, 6 and 7, respectively, from reaction with alcohols or Nnucleophiles. The acid chloride (3) was also converted easily into the new derivatives consisting of 5-phenyl-1H-pyrazole 8a,b. The cyclocondensation reactions of 2 with some hydrazines led to the f Read More

The accurate determination of ethanol is important in food technology, forensic laboratories, as well as in clinical analysis. Methods of ethanol assessment include spectrometry, gas chromatography, high performance liquid chromatography, but also biosensors, mainly with electrochemical or optical detection. The purpose of this study is the investigation of the role and influence of alcohol dehydrogenase and horseradish pe Read More