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2000
Volume 19, Issue 12
  • ISSN: 1570-1786
  • E-ISSN:

Abstract

Many therapeutically important nucleoside analogues can be synthesized from versatile azidonucleoside intermediates. We have synthesized 3’-xylo-azidonucleoside analogues of thymidine and 2’-deoxyadenosine via Mitsunobu-DPPA and triflate-lithium azide strategies. On comparing the two azidation strategies on nucleoside analogues, we found that Mitsunobu-DPPA azidation is better than triflate-lithium azide azidation in terms of yield and reaction conditions.

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/content/journals/loc/10.2174/1570178619666220621112018
2022-12-01
2024-11-23
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  • Article Type:
    Research Article
Keyword(s): azidation; DPPA; lithium azide; Mitsunobu; nucleosides; triflate
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