Tungstate Sulfuric Acid (TSA): A Green and Highly Efficient Catalyst for Novel and Known Polysubstituted Imidazoles Synthesis

Tungstate sulfuric acid (TSA) was composed of anhydrous sodium tungstate and chlorosulfonic acid with a new modified and efficient method. Catalyst was characterized by powdered X-ray diffraction (XRD), X-ray fluorescence (XRF), FT-IR spectroscopy and titration with NaOH (0.1 N). In the present study, highly efficient role of TSA as a catalyst in polysubstituted imidazoles synthesis as pharmaceuticaly important molecules via condensation between a wide range of aryl aldehydes, primary amines, benzil, and ammonium acetate in solventless conditions is reported. Therefore, new application of this catalyst to synthesize some novel imidazoles is introduced.