An Efficient Synthesis of Some New Hydrazone Derivatives Containing 1,2,3-Triazole and Thiazole

The syntheses of hydrazone derivatives with thiazole and triazole rings were described. The target compounds 7a-j and 8a-g with the hydrazine based structure containing thiazole and triazole rings were synthesized respectively through the reactions of α-bromomethylpyrazole ketone 3 with arylethanone thiosemicarbazones 5a-j and the reactions of pyrazol thiosemicarbazone 4 with &agr:-bromomethyl aryl ketones 6a-g under reflux condition without catalyst. Furthermore, an eco-friendly convenient method for the synthesis of compounds 8a-g was developed using one-pot route. The target compounds were tested for preliminary bioactivities by using H2O2-induced PC 12 cells with oxidative injury.