Fine-Tuning of Acid Susceptibility of 4, 4’-Dimethoxytrityl Ether Derivatives by a Methoxy Group Introduced via a Styryl Substituent

To overcome the problem of depurination in oligoDNA synthesis, we tried to fine-tune the acid lability of the DMTr group by adding a substituted styryl group on the phenyl ring. The styryl groups could buffer the electron donating nature of the methoxy group and enabled the fine-tuning of the acid lability.