Synthesis and Cellular Uptake of Fluorescently Labeled 1-Chloromethyl-5- Hydroxy-1, 2-Dihydro-3H-Benz [e] Indole (Seco-CBI)- Pyrrole Polyamide Conjugates

Rohtash Kumar; Dinesh Rai; Sandra L. Marcus; Simon C. Chun Ko; J. William Lown

doi:10.2174/1570178043488383

ISSN: 1570-1786
E-ISSN: 1875-6255

Synthesis and Cellular Uptake of Fluorescently Labeled 1-Chloromethyl-5- Hydroxy-1, 2-Dihydro-3H-Benz [e] Indole (Seco-CBI)- Pyrrole Polyamide Conjugates
Authors: Rohtash Kumar¹, Dinesh Rai², Sandra L. Marcus³, Simon C. Chun Ko⁴ and J. William Lown⁵
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¹ Department of Chemistry, University of Alberta, Edmonton, AB, Canada, T6G 2G2. ² Department of Chemistry, University of Alberta, Edmonton, AB, Canada, T6G 2G2. ³ Department of Chemistry, University of Alberta, Edmonton, AB, Canada, T6G 2G2. ⁴ Department of Chemistry, University of Alberta, Edmonton, AB, Canada, T6G 2G2. ⁵ Department of Chemistry, University of Alberta, Edmonton, AB, Canada, T6G 2G2.
Source: Letters in Organic Chemistry, Volume 1, Issue 2, Apr 2004, p. 154 - 158
DOI: https://doi.org/10.2174/1570178043488383
- Available online: 01 Apr 2004

Abstract

The synthesis is described of 1-chloromethyl-5-hydroxy-1, 2-dihydro-3H-benz [e] indole (seco- CBI)- pyrrole polyamide conjugates (1-4) which were labeled with a fluorescent Fmoc moiety to evaluate their cellular uptake. Confocal laser scanning microscopy (CLSM) indicates that these DNA minor groove-binding agents localize in the cytoplasm and organelles.

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2004-04-01

2025-06-23

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Article Type: Review Article

Keyword(s): 1-chloromethyl-5- hydroxy-1, 2-dihydro-3h-benz [e] indole; fluorescent fmoc; groove-binding agents; pyrrole polyamide conjugates

Synthesis and Cellular Uptake of Fluorescently Labeled 1-Chloromethyl-5- Hydroxy-1, 2-Dihydro-3H-Benz [e] Indole (Seco-CBI)- Pyrrole Polyamide Conjugates

Abstract

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