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Volume 1, Issue 1
  • ISSN: 2666-9390
  • E-ISSN: 2666-9404

Abstract

Background & Purpose

Diabetes is a disease that has affected many people worldwide. According to the World Health Organization, approximately 80% of humans still rely on conventional or folk medicament in developed countries. The effectiveness of herbal medicines was credited to the phytochemical components.

Objective

This review aims to highlight the pathological pathways of diabetes and the antidiabetic mechanism of phytochemicals.

Materials and Methods

This organized search was compiled from the databases such as PubMed, Scopus, Embase, Science Direct, Web of Science, and Google Scholar till February 2023.

Results

Inflammatory and oxidative stress are mainly two examples of pathological pathways of diabetes that are explored. The reported antidiabetic phytochemicals work by increasing insulin secretion, lowering hepatic glucose output, controlling specific enzymes, and utilizing other mechanisms. For instance, studies on α-glucosidase inhibitors, modulation peroxisome proliferator-activated receptor-α, hypolipidaemic activity, antioxidants, inhibition of glycolytic enzymes like phosphoenolpyruvate carboxykinase, improvement of glycosylated haemoglobin and increased expression of glucose transporters have been conducted.

Conclusion

Many natural secondary metabolites (phytochemicals) have significant potential for the manufacture of marketable, new, and efficient anti-diabetic medicines which can be used for clinical purposes.

© 2024 Bentham Science Publishers
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2023-09-25
2024-11-22

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/content/journals/lff/10.2174/2666939001666230718142652
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An Outlook on Pathological Pathways of Diabetes and Molecular Mechanisms of Anti-diabetic Phytobioactives
Lett Funct Foods 1, e180723218858 (2024); https://doi.org/10.2174/2666939001666230718142652
/content/journals/lff/10.2174/2666939001666230718142652
/content/journals/lff/10.2174/2666939001666230718142652
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  • Article Type:     Review Article
Keyword(s): anti-diabetic medicines; Diabetes; inflammatory; oxidative stress; pathological; phytobioactives

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