Letters in Drug Design & Discovery

Letters in Drug Design & Discovery - Online First

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- A Theoretical Study on Derivatives of 1,2,4-trioxane as Potential Anti-malarials and an Analysis of the Mechanism of Drug Release in the Presence of Fe(III) Ions
  
  By Zakiyeh Bayat
  
  https://doi.org/10.2174/0115701808299016240916083229
  
  Available online: 01 October 2024
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  Introduction A mechanism has been proposed for the targeted transfer of an antimalarial drug, which involves 1, 2, and 4 trioxane (TRX) reagents. The trioxane ring is sensitive to ferrous iron, Fe)II(, and when exposed to it, it breaks down into smaller pieces, releasing the antimalarial drug mML (a mock form of DPA1 inhibitor ML4118S). Method The oxane ring is attached to a nanoparticle called adamantane, which helps facilitat Read More

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- Discovery, Structural Determination and Anticancer Activities of Lactucinlike Guaianolides
  
  Authors: Yulin Ren, Yawei Zhou, Xiaozhuo Chen and Yunhua Ye
- Thermodynamic Aspects of Cancer: Possible Role of Negative Entropy in Tumor Growth, its Relation to Kinetic and Genetic Resistance
  
  Authors: Joseph Molnar, Barry S. Thornton, Annamaria Molnar, Dezso Gaal, Liaofu Luo and Elke S. Bergmann-Leitner
- Immunomodulatory Properties of Synthetic Imidazolone Derivatives
  
  Authors: M. A. Mesaik, K. M. Khan, S. Rahat, Zia-Ullah, M. I. Choudhary, S. Murad, N. R. Abdullah, Atta-ur-Rahman, A. Ahmad and R. A. Siddiqui
- Design and Prediction of ADME/Tox Properties of Novel Magnolol Derivatives as Anticancer Agents for NSCLC Using 3D-QSAR, Molecular Docking, MOLCAD and MM-GBSA Studies
  
  Authors: Ossama Daoui, Souad Elkhattabi and Samir Chtita
- Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease
  
  Authors: Kazuhiro Honda, Paula I. Moreira, Quan Liu, Sandra L. Siedlak, Xiongwei Zhu, Mark A Smith and George Perry
- Identifying Protein Binding Sites and Optimal Ligands
  
  Authors: Albert Beuscher, Arthur J. Olson and David S. Goodsell
- Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part I: Amides and Ureas
  
  Authors: B. Crescenzi, M. Poma, J. M. Ontoria, A. Marchetti, E. Nizi, V. G. Matassa and C. Gardelli
- Phenyldihydroxypyrimidines as HCV NS5B RNA Dependent RNA Polymerase Inhibitors. Part II: Sulfonamides
  
  Authors: S. Ponzi, C. Giuliano, M. Donghi, M. Poma, V. G. Matassa and I. Stansfield
- Selection of a Catalytically Active Enzyme In Vivo Via Phage Display of its Product
  
  Authors: T. Taki, S. Fujita and K. Taira
- A Comprehensive Review of the Advancement in Omic Technologies in the Field of Drug Discovery and Development
  
  Authors: Mridula Chauhan, Shivansh Kumar, Arpon Biswas, Mukesh Kumar, Sarvesh Kumar Verma, Anjali Mishra, Vaishali Singh, Amol Chhatrapati Bisen, Sristi Agrawal, Abhijit Deb Choudhury, Ramakrishna Rayiti and Rabi Sankar Bhatta
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Letters in Drug Design & Discovery - Online First

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