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2000
Volume 16, Issue 6
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: In search of novel anticancer agents, a series of 1,3,4-oxadiazole derivatives (12a-j) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by 1HNMR, 13CNMR and ESI-MS spectral analysis. Methods: Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A549 (lung), MCF-7 (breast), A375 (melanoma) and HT-29 (colon). Results: Here, CA4 used as positive control. Among them, compounds 12b, 12c, 12f, 12g, 12h and 12j were exhibited promising activity than control drug. Conclusion: In conclusion, we have synthesized a novel series of 1,3,4-oxadiazole fused 1,3,4- thiazdiazole derivatives and their structures were confirmed by spectral analysis.

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/content/journals/lddd/10.2174/1570180816666181031125946
2019-06-01
2025-07-09
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  • Article Type:
    Research Article
Keyword(s): anticancer activity; megazol; melanoma; Methazolamide; MTT assay; zibotentan
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