Skip to content
2000
Volume 16, Issue 5
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: The present paper focuses on the in vitro inhibition of some sedative drugs such as Midazolam, Propofol, Hipnodex, Ketamine, and Pental sodium on acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), and α-glycosidase (α-Gly) enzymes. Methods: These drugs were tested in diverse concentrations, which showed positive effects in vitro AChE, BChE, and α-Gly activities. Ki values were 20.14, 94.93, 636.78, 416.42, and 953.75 μM for AChE, 17.52, 32.03, 88.02, 93.48, and 91.84 μM for BChE, and 10.87, 156.68, 48.21, 37.88, 151.01 μM for α-glycosidase, respectively. Results: An enhancing number of experiential observations show potentially harmful effects of sedative drugs on the extension of brain. Conclusion: Midazolam exhibited effective inhibitory activity compared with the other drugs for these enzymes.

Loading

Article metrics loading...

/content/journals/lddd/10.2174/1570180815666180924110023
2019-05-01
2025-07-08
Loading full text...

Full text loading...

/content/journals/lddd/10.2174/1570180815666180924110023
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test