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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Design and Synthesis of Benzopyranopyrimidinyl Phosphonates as Cytotoxic and Antioxidant Agents
- Source: Letters in Drug Design & Discovery, Volume 16, Issue 7, Jul 2019, p. 721 - 733
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- 01 Jul 2019
Abstract
Background: A concatenation of bioactive diethyl(2-hydroxyphenylsubstituted) benzopyrano pyrimidinyl phosphonates were synthesized under eco-friendly green conditions in the presence of palladium doped graphitic carbon nitride (Pd@g-C3N4) as catalyst. Methods: The title compounds were evaluated for cytotoxic activity against MCF-7, SW-480, HeLa and HL-7702 cell lines and in-vitro antioxidant activity by DPPH, NO and H2O2 methods. Results: The synthesized compounds manifested robust cytotoxic and antioxidant activities. Conclusion: Some of them showed much higher bioactivity than the standards.
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