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2000
Volume 15, Issue 12
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: A series of new 6-(tert-butyl)-8-chloro-2,3-dimethyl quinoline derivatives were designed and synthesized. Results: The primarily antifungal assay results indicated that all of them exhibited excellent protective efficacy (100%) against Pyricularia oryae at 100 ppm, except compound 2m (90%). Among them, the compound 2p (6-(tert-butyl)-8-chloro-2,3-dimethylquinolin-4-yl(2-chloro-5- (trifluoromethyl)benzyl)carbonate) possessed the highest fungicidal efficacy against Pyricularia oryae, even at 10 ppm. Conclusion: The structure-activity relationship showed that when the 2-position of benzene ring was substituted by F or Cl, the compound possessed good antifungal activity against Pyricularia oryae.

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/content/journals/lddd/10.2174/1570180815666180313121735
2018-12-01
2025-07-15
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  • Article Type:
    Research Article
Keyword(s): antifungal activity; benzene; heterocyclic compounds; Pyricularia oryae; Quinoline; SAR
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