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2000
Volume 15, Issue 12
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: CDK2 shows a fundamental role as a controller of cell growing, which makes it as one of the goals of anticancer inhibitors. Methods: The current study participated in design (docking and binding energy), which used to select the promising proposed compounds, synthesis of novel diverse 14 pyrido[2,3-d]pyrimidine derivatives and biological studies of the prepared compounds as promising anticancer agents aiming CDK2. All the fresh generated compounds were scanned for their anticancer activity versus MCF-7 and CaCO2 and 14 compounds were found to be active. Compounds 6c and 8d displayed expressive activity with IC50 values 7.4 and 5.5 on MCF-7 respectively. The created compounds were submitted to enzyme inspection (CDK2) for assigning their inhibitory activity. Results: The initial results showed that compound 8d, which demonstrates potent inhibitory activity towards tumor development and powerful inhibitions of CDK2 enzyme (89% inhibition) could be utilized as a lead candidate. The products were characterized by IR, 1H NMR, 13CNMR and MS. Conclusion: Preliminary bioassays indicated that most of the compounds exhibited very good antitumor activity and powerful inhibitions of CDK2 enzyme.

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/content/journals/lddd/10.2174/1570180815666180219163254
2018-12-01
2025-10-20
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/content/journals/lddd/10.2174/1570180815666180219163254
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