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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Bioevaluation of Shikonin Derivatives
- Source: Letters in Drug Design & Discovery, Volume 15, Issue 9, Sep 2018, p. 945 - 950
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- 01 Sep 2018
Abstract
Background: Ester and amide derivatives of shikonin were synthesized to improve the chemical stability of shikonin. Methods: All synthesized compounds were evaluated for their antiproliferative activity against A549 cell line by SRB assay, and five of them demonstrated comparable cytotoxicity to shikonin. Results and Conclusion: The most potent compound, 22d, was more stable and potent than shikonin.
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