Skip to content
2000
Volume 15, Issue 7
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: Aldose reductase is the key enzyme in the polyol pathway, it is implicated in the development of complications associated with diabetes. Objective: The aim of this review is to classify the medicinal plants and their phytoconstituents used in the inhibition of aldose reductase. Methods: We reviewed 83 papers published between 1997 and 2015 (PubMed and Sciencedirect). All the molecules structures were provided in ChemDraw software. Results and Conclusion: In this work we have listed the experiments that have showed therapeutic effect of aldose reductase inhibitors against complications associated with diabetes. We concluded that aldose reductase inhibitors have common components that are responsible for their inhibitory activity. Quercetin, Luteolin 6-C-(6´´-transcaffeoylglucoside), 1,5-di-O-caffeoylquinic acid, Quercetrin, 3,5-Di-O-caffoeylquinic acid, chlorogenic acid, 3,4,5-tri-O-caffeoylquinic acid, kuraridin, Methyl-3,5-di-O-caffeoylquinate, 3, 5-di-Ocaffeoylquinic acid, isoquercitrin, kaempferol-3-O-[2", 6"-di-O-(E)-p-coumaroyl]-β-D-glucopyranoside, desmethylanhydroicaritin, kaempferol-3-O-[2", 6"-di-O-(E)-p-coumaroyl]-β-D-galactopyranoside, casuariin, casuarinin, Luteolin, Methyl-3,5-di-Ocaffeoylquinate, Lavandulylkaempferol, 3,5-di-O caffeoylquinic acid methyl ester, kushenol C, and Desmethylanhydroicaritin showed significant inhibitory potential of aldose reductase.

Loading

Article metrics loading...

/content/journals/lddd/10.2174/1570180814666171011163954
2018-07-01
2025-06-23
Loading full text...

Full text loading...

/content/journals/lddd/10.2174/1570180814666171011163954
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test