Microwave-promoted Synthesis of S-substituted Quinazoline Derivatives using 1,4-dihydroquinazoline-2-thiol

A novel, rapid and efficient microwave-assisted synthesis of S-substituted quinazoline derivatives was obtained using 1,4-dihydroquinazoline-2-thiol and various boronic acids with copper catalyst in one-pot reactions. The versatility of the synthetic protocol with various boronic acids and the optimization processes of the microwave irradiation conditions including temperature, solvent, and reaction time were demonstrated.