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2000
Volume 15, Issue 2
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: In the present study, new triazine derivatives 3, 4, 5, 6, 8 and 10 were synthesized starting from readily available cyanuric chloride 1 via nucleophilic displacement with morpholine followed by Suzuki or Stille coupling reactions and then the thermal displacement of chlorine atom with diverse substituted amines. Methods: All synthesized compounds were screened for their cytotoxic activity against HT-29, MDA-MB-231, and HEK293 cell lines. Results and Conclusion: Compounds 6a (IC50 (μM): 0.32 for HT-29 and 2.92 for MDA-MB-231) and 8c (IC50 (μM): 1.40 for HT-29 and 1.60 for MDA-MB-231) have been identified and compared with Doxorubicin and ZSTK474 as the reference standards.

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/content/journals/lddd/10.2174/1570180814666170605115335
2018-02-01
2025-07-12
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/content/journals/lddd/10.2174/1570180814666170605115335
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