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2000
Volume 15, Issue 2
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: We report the design, synthesis and evaluation of a series of 4-biaryl substituted 2-amino benzo[h]chromene derivatives as potential cytotoxic agents. Methods: The one-pot synthesis of this class of compounds was carried out under ultrasound irradiation using an MCR involving Pd/C-catalyzed Suzuki-Miyaura coupling as a key step. Result and Conclusion: Several of these compounds showed promising cytotoxicities when tested against cancer cell lines but no or little effects on non-cancerous cell lines.

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/content/journals/lddd/10.2174/1570180814666170530094023
2018-02-01
2025-07-04
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  • Article Type:
    Research Article
Keyword(s): 2-amino benzo[h]chromene; cytotoxic agents; cytotoxicity; MCR; Pd/C; potential treatment
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