Synthesis and Antimicrobial Activity of Some Novel Substituted 3-(Thiophen-2-yl)pyrazole-based Heterocycles

Background: A series of novel substituted 3-(thiophen-2-yl)pyrazoles was synthesized efficiently and in high yields using simple and convenient procedures starting from 1-phenyl-3- (thiophen-2-yl)-1H-pyrazole-4-carbaldehyde. Methods: The structures of the newly synthesized products were established and their antimicrobial activities were investigated against some bacteria and fungi. Results and Conclusion: The products showed excellent antimicrobial activities against the tested microorganism compared to the standard antibacterial and antifungal drugs.