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2000
Volume 14, Issue 10
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Background: Acetic acid alone when employed as a solvent under ultrasound irradiation has been found to be effective for the three-component reaction involving ethyl-5- amino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the presence of aerial oxygen. Methods: The catalyst / promoter / ligand free method afforded a range of pyrazolo[1,5-a] pyrimidines as potential and new cytotoxic agents. Results and Conclusion: While some of these compounds showed cytotoxicities against two breast cancer cell lines one of them was found to be promising.

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/content/journals/lddd/10.2174/1570180814666170126120408
2017-10-01
2025-07-09
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/content/journals/lddd/10.2174/1570180814666170126120408
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  • Article Type:
    Research Article
Keyword(s): 5-a]pyrimidine; acetic acid; anti-tumor; drug discovery; MCR; pyrazolo[1; Ultrasound
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