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2000
Volume 14, Issue 2
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A series of new biologically potent N-substitutedpyrazoline derivatives have been synthesized by reacting hydrazine hydrate and its derivatives with (2)-1-(4-chlorophenyl)-3-[4-(propan-2- yl)phenyl]prop-2-en-1-one, which in turn prepared by the base catalysed Claisen-Schmidt condensation reaction of 4-(propan-2-yl)benzaldehyde and 4-chloroacetophenone. All the synthesized compounds, 2a-e, 3a-d, 4a,b and 5a-c were screened for their in vitro antibacterial, antioxidant, antiproliferative properties and compounds 3b, 4b were evaluated for in vivo anti-inflammatory activity. The docking studies were carried out for these compounds against α-amylase with TREX1 (PDB:3B60) to predict their putative interactions. Some of the tested compounds showed significant antibacterial, antioxidant, antiproliferative, anti-inflammatory activity and molecular binding.

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/content/journals/lddd/10.2174/1570180813666160519151723
2017-02-01
2025-06-12
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