Skip to content
2000
Volume 12, Issue 7
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

In the present study, a series of dibenzoazepine triazole derivatives (24-39) were synthesized and evaluated for their in vitro bioactivities including antiglycation, antibacterial, DPPH radical scavenging, urease inhibition, antileishmanial and immunomodulatory activities. The compounds were found to be moderately active only against leishmania. Within this series, compound 26 was found to be the most active antileishaminals with IC50 value 37.4 ± 0.4 μM. Structure-activity relationships for this novel class are discussed.

Loading

Article metrics loading...

/content/journals/lddd/10.2174/1570180812999150225111959
2015-08-01
2025-07-08
Loading full text...

Full text loading...

/content/journals/lddd/10.2174/1570180812999150225111959
Loading

  • Article Type:
    Research Article
Keyword(s): antileishmanial; click chemistry; Dibenzoazepine; iminostilbene; immunomodulatory; triazoles
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test