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2000
Volume 13, Issue 5
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

Furazano[3,4-b]quinoxaline 1-oxides indicate significant chemical reactivity and release NO fragments in their electron impact mass spectra. A series of fused furazan N-oxide derivatives were synthesized and tested in vitro as potential NO releasing agents in the presence of L- cysteine used as a thiol cofactor. The synthesized compounds were determined using cysteine as cofactor and Griess reagent. The yield in nitrite for each compound was expressed as % NO2- (mol/mol). Compound 4c showed the higher NO releasing ability among the tested furazan N-oxide derivatives. A new class of NO-donors, Furazano[3,4-b]quinoxaline 1-Oxides hybrids was developed by joining NOdonor furoxan moiety to substituted quinoxaline 1-Oxides. It seems that lipophilicity and stereochemistry of the X substitution influences the NO donating behavior.

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/content/journals/lddd/10.2174/1570180812666150923235828
2016-06-01
2025-07-03
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  • Article Type:
    Research Article
Keyword(s): 4-b]quinoxaline 1-Oxides; furazano[3; griess; Nitric oxide; NO donors
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