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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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Synthesis and Biological Activity of Novel N-glucosides Containing Substituted Piperazine Moiety
- Source: Letters in Drug Design & Discovery, Volume 13, Issue 4, May 2016, p. 343 - 351
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- 01 May 2016
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Abstract
A series of novel acetylated piperazine-containing N-glucosides and bis(Nglucoside) 8a-i were synthesized by the nucleophilic addition of acetylated glucopyranosyl isothiocyanate with various substituted piperazines in THF with high yields. Their novel deacetylated products 9a-i were also synthesized after Me- ONa/MeOH treatment. The preliminary bioassays for 18 novel title compounds showed that several compounds have significant fungicidal activity against Fusarium omysporum, Cercospora arachidicola and Phytophthora capsici at 50 μg/mL.
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