Application of Sustained-release Carrier of NanoAg-Epidermal Growth Factor in Promoting Refractory Diabetic Wound Healing

Objective: This study aimed to elucidate the antibacterial properties and therapeutic effect in refractory diabetic wound healing of a NanoAg-epidermal growth factor sustained-release carrier(NanoAg-EGF). Methods: as previous publishing, the sustained-release carrier of NanoAg-EGF can be conducted. The antibacterial properties and therapeutic effects of NanoAg-EGF were determined through in vitro bacterial growth inhibition experiments and in vivo wound healing experiments in diabetic rats. Results: In antibacterial experiments, NanoAg-EGF had strong properties of antibacterial which is similar to those of NanoAg (p>0.05). In diabetic wound healing experiments, NanoAg-EGF significantly shortened the wound healing time. Furthermore, at 3 days after wounding, the healing rate of each group was no different (p>0.05). However, at 7 and 13 days after wounding, with being higher than other four groups, the healing rates of sustained-release carrier treated diabetic rats were remarkable (p<0.05). Conclusion: NanoAg-EGF not only has good antibacterial properties, but can also promote rapid wound healing in diabetes.