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2000
Volume 12, Issue 5
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A series of di-substituted cinnamic hydroxamic derivatives was designed, synthesized and evaluated as HDAC inhibitors. Compound 5f (HS270) demonstrated potent HDAC inhibitory and antiproliferative activities. In xenograft model, 5f showed significant antitumor efficacy in tumorbearing mice.

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/content/journals/lddd/10.2174/1570180811666141024004832
2015-06-01
2025-06-16
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/content/journals/lddd/10.2174/1570180811666141024004832
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  • Article Type:
    Research Article
Keyword(s): Antitumor; cinnamic; design; HDAC; histone deacetylase; hydroxamaic acid
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