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- ISSN: 1570-1808
- E-ISSN: 1875-628X
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The Synthesis of Risedronic Acid and Alendronate Applying Phosphorus Oxychloride and Phosphorous Acid in Methanesulfonic Acid
- Source: Letters in Drug Design & Discovery, Volume 12, Issue 4, May 2015, p. 253 - 258
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- 01 May 2015
Abstract
The synthesis of risedronic acid and alendronate from 3-pyridylacetic acid and γ- aminobutyric acid, respectively, using phosphorus oxychloride and phosphorous acid as the P-reagents and methanesulfonic acid as the solvent was optimized, and the role of phosphorus oxychloride and phosphorous acid in the reaction was clarified.
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