Synthesis, Characterization and Microbial Activity of New Bisphenol-C Derivatives

A series of bisphenol-C derivatives was synthesized by condensing bisphenol-C with benzylchloride, alkylchloroacetates and alkylchloroformates in the presence of anhyd. K2CO3 in THF using catalytic amount of PEG-600. The compounds were characterized by FTIR, 1HNMR, 13CNMR and MS; and assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E. coli MTCC-443, S. typhi MTCC-98 and antifungal activity against A. niger MTCC-282 and A. clavatus MTCC-1323 at different concentrations and compared with standard drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method. 1a-c, 1e-g and 2b-g showed moderate to comparable antibacterial activity against E. coli, S .typhi, B. subtillis and S. aureus. All of these compounds did not show antifungal activity. Increasing hydrophobic chain length, methyl side substituent and aromatic ring affected considerably antibacterial activity.