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2000
Volume 11, Issue 10
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

In the present study, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-(4-arylthiazol-2-yl)] derivatives (3a-h) were obtained via the reaction of 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1- carbothioamide] (2) with phenacyl bromides. The synthesized compounds were investigated for their antimicrobial activity against various bacteria and Candida species. Among these derivatives, 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5- dihydro-1H-pyrazole-1-(4-(4-chlorophenyl)thiazol-2-yl)] (3b) and 5,5'-(1,4-phenylene)bis[3-(2-thienyl)-4,5-dihydro-1Hpyrazole- 1-(4-(4-methoxyphenyl)thiazol-2-yl)] (3d) showed notable antimicrobial activity.

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/content/journals/lddd/10.2174/1570180811666140717185937
2014-12-01
2025-06-11
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/content/journals/lddd/10.2174/1570180811666140717185937
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  • Article Type:
    Research Article
Keyword(s): Antimicrobial activity; pyrazole; thiazole
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