Skip to content
2000
Volume 11, Issue 10
  • ISSN: 1570-1808
  • E-ISSN: 1875-628X

Abstract

A series of novel salicylic acid-based 1,3,4-oxadiazoles derivatives coupled with chiral oxazolidinones were synthesized to screen for their in vitro antitumor activity against five human cancer cell lines. Some of these compounds showed good antitumor activities with IC50alues ranging from 31.19-57.21 µM. Among the tested compounds 11, 15, 19, 23, 24, and 34 showed broad-spectrum antitumor activity against all the cell lines. In particular, compound 19 revealed remarkable antitumor activity with IC50 = 31.19-41.87 µM. A431 was the most sensitive cell line against all the compounds studied, followed by HeLa, MCF-7, A549 and HepG2. Structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and HRMS spectral data.

Loading

Article metrics loading...

/content/journals/lddd/10.2174/1570180811666140627004607
2014-12-01
2025-07-12
Loading full text...

Full text loading...

/content/journals/lddd/10.2174/1570180811666140627004607
Loading

  • Article Type:
    Research Article
Keyword(s): 1; 3; 4-oxadiazoles; antitumor activity; chiral oxazolidinones; MTT essay; salicylic acid
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test